Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Human telomeric DNA consists of tandem repeats of the sequence d (TTAGGG). The
formation and stabilization of DNA G-quadruplexes in the human telomeric sequence have …

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions
at the ends of macronuclear chromosomes. We have now identified homologous proteins in …

The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …