Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing
protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the inflammatory …

Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian
countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines. Traditionally, it …

Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae
family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and …

The placenta is particularly susceptible to inflammation and oxidative stress, leading to
placental vascular dysfunction and placental insufficiency, which is associated with fetal …

Background and objectives: Oleanolic acid (OA) is a penta-cyclic triterpene with diverse
bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti …

Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis
(PSC), and IgG4-related sclerosing cholangitis (IgG4-SC) are the four main forms of …

Colon cancer (CC) is a prevalent malignant tumor of the gastrointestinal tract and ranks
among the leading causes of death in cancer patients worldwide. Cucurbitacin, a group of …