Emerging artificial intelligence (AI) technologies used in the development of solid dosage forms

J Jiang, X Ma, D Ouyang, RO Williams III - Pharmaceutics, 2022 - mdpi.com
Artificial Intelligence (AI)-based formulation development is a promising approach for
facilitating the drug product development process. AI is a versatile tool that contains multiple …

The artificial intelligence-powered new era in pharmaceutical research and development: A review

P Suriyaamporn, B Pamornpathomkul… - AAPS …, 2024 - Springer
Abstract Currently, artificial intelligence (AI), machine learning (ML), and deep learning (DL)
are gaining increased interest in many fields, particularly in pharmaceutical research and …

Application of ensemble machine learning approach to assess the factors affecting size and polydispersity index of liposomal nanoparticles

B Hoseini, MR Jaafari, A Golabpour… - Scientific Reports, 2023 - nature.com
Liposome nanoparticles have emerged as promising drug delivery systems due to their
unique properties. Assessing particle size and polydispersity index (PDI) is critical for …

Progress on thin film freezing technology for dry powder inhalation formulations

SR Pardeshi, EB Kole, HS Kapare, SM Chandankar… - Pharmaceutics, 2022 - mdpi.com
The surface drying process is an important technology in the pharmaceutical, biomedical,
and food industries. The final stage of formulation development (ie, the drying process) faces …

[HTML][HTML] The applications of machine learning to predict the forming of chemically stable amorphous solid dispersions prepared by hot-melt extrusion

J Jiang, A Lu, X Ma, D Ouyang… - International Journal of …, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the
solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to …

Optimization of computational intelligence approach for the prediction of glutinous rice dehydration

KA Jimoh, N Hashim, R Shamsudin… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Five computational intelligence approaches, namely Gaussian process
regression (GPR), artificial neural network (ANN), decision tree (DT), ensemble of trees …

A multi-step machine learning approach for accelerating QbD-based process development of protein spray drying

D Fiedler, E Fink, I Aigner, G Leitinger, W Keller… - International Journal of …, 2023 - Elsevier
This study proposes a new material-efficient multi-step machine learning (ML) approach for
the development of a design space (DS) for spray drying proteins. Typically, a DS is …

Advances in Artificial Intelligence in Drug Delivery and Development: A Comprehensive Review

AD Gholap, MJ Uddin, M Faiyazuddin, A Omri… - Computers in Biology …, 2024 - Elsevier
Artificial intelligence (AI) has emerged as a powerful tool to revolutionize the healthcare
sector, including drug delivery and development. This review explores the current and future …

Sensitivity analysis and uncertainty quantification of nanoparticle deposition from tongue morphological variations

T Yang, X Si, J Xi - Life, 2024 - mdpi.com
The human tongue has highly variable morphology. Its role in regulating respiratory flows
and deposition of inhaled aerosols remains unclear. The objective of this study was to …

Unraveling the influence of solvent composition on Drop-on-Demand binder jet 3D printed tablets containing calcium sulfate hemihydrate

A Lu, I Duggal, BA Daihom, Y Zhang… - International Journal of …, 2024 - Elsevier
Recently, binder jet printed modular tablets were loaded with three anti-viral drugs via Drop
on Demand (DoD) technology where drug solutions prepared in ethanol showed faster …