Adrenocortical carcinoma (ACC) is a rare endocrine malignancy arising from the adrenal
cortex often with unexpected biological behavior. It can occur at any age, with two peaks of …

Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis. Most tumors are
either metastatic or locally invasive at the time of diagnosis. Differentiation between ACC …

Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC).
However, limited evidence is available regarding the impact of plasma mitotane levels on …

Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to
conventional chemotherapeutics agents. Early diagnosis, followed by radical surgical …

Immunotherapy is widely used in the treatment of different cancer types, including metastatic
melanoma, non-small cell lung cancer, renal cell carcinoma and urothelial cancer. The …

Mitotane is used as a post-operative adjuvant treatment for patients with adrenocortical
carcinoma. Monitoring of plasma mitotane concentrations is recommended, but we do not …

Simple Summary Mitotane is the only drug approved for treatment of adrenocortical cancer.
Although mitotane is a derivative of the pesticide dichlorodiphenyltrichloroethane (DDT) …

A relevant issue on the treatment of adrenocortical carcinoma (ACC) concerns the optimal
duration of adjuvant mitotane treatment. We tried to address this question, assessing …

Adrenocortical carcinoma (ACC) is a rare malignancy that is frequently asymptomatic at
presentation, yet has a high rate of metastatic disease at the time of diagnosis. Prognosis is …

Objective Thapsigargin (TG) is a natural product that exists in most parts of the plant Thapsia
garganica L. and possesses potential anticancer activities against variety tumor cell lines …