Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …
however, growing evidence suggests that they are also significantly involved in cancer, the …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
Crosstalk between platelets and microbial pathogens
Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …
Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies
Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play
key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA …
key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA …
In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα
The interaction of platelet GPIbα with von Willebrand factor (VWF) is essential to initiate
platelet adhesion and thrombosis, particularly under high shear stress conditions. However …
platelet adhesion and thrombosis, particularly under high shear stress conditions. However …
Extracellular matrix proteins in the regulation of thrombus formation
Extracellular matrix proteins in the regulation of thrombus... : Current Opinion in Hematology
Extracellular matrix proteins in the regulation of thrombus formation : Current Opinion in …
Extracellular matrix proteins in the regulation of thrombus formation : Current Opinion in …
Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Ischemic stroke is a leading cause of death and disability worldwide. Increasing evidence
indicates that ischemic stroke is a thromboinflammatory disease in which the contact–kinin …
indicates that ischemic stroke is a thromboinflammatory disease in which the contact–kinin …
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy
G Zhu, Q Zhang, EC Reddy, N Carrim… - Blood, The Journal …, 2017 - ashpublications.org
Integrins are a large family of heterodimeric transmembrane receptors differentially
expressed on almost all metazoan cells. Integrin β subunits contain a highly conserved …
expressed on almost all metazoan cells. Integrin β subunits contain a highly conserved …
Fibronectin maintains the balance between hemostasis and thrombosis
Fibronectin is a dimeric protein widely distributed in solid tissues and blood. This major
extracellular matrix protein is indispensable for embryogenesis and plays crucial roles in …
extracellular matrix protein is indispensable for embryogenesis and plays crucial roles in …