Most Annonaceous acetogenins are characterized by between one and three THF ring (s)
with one or two flanking hydroxyl group (s) in the center of a C32/34 fatty acid, and the …

Ecuador is well known for its biodiversity and its ancient richness. This review provides an
overview of Ecuadorian plant species in terms of the ethnobotany and chemistry of natural …

Novel naphthoquinones were designed, synthesized, and tested as substrate-based
inhibitors against the membrane-embedded protein quinol/fumarate reductase (QFR) from …

In our ongoing research program into the discovery of new anticancer drugs, we were
interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side‐chains …

Background Histone modifications in tumorigenesis are increasingly recognized as
important epigenetic factors leading to cancer. Increased phosphorylation levels of histone …

Various plants have been used against cancer in the traditional systems of medicine in the
South American countries, since many years. The indigenous people, population, or special …

Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but
discrepancies in the structure/activity relationships pled the search for other targets within …

Annonaceous acetogenins (AGEs) are potential phytochemicals of herbal medicines and
exhibit a wide variety of biological activities.[1] Recent work has demonstrated that AGEs …

Abstract A “Building Block Approach” for the synthesis of various quinone‐amino acid
hybrids through ethylene cross‐enyne metathesis and Diels–Alder reaction as key steps is …

A small library of squamocin analogues has been prepared and screened biologically
(cytotoxicity, inhibition of mitochondrial complex I and complex III). To centre diversity on a …