Translational research has revolutionized how we develop new treatments for cancer
patients. The change from an organ-centric concept guiding treatment choice towards deep …

Breast cancer affects millions of women each year. Despite recent advances in targeted
treatments breast cancer remains a significant threat to women's health. In recent years the …

The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …

Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To
support this malignant phenotype, cells acquire molecular alterations that abrogate or …

Introduction The majority of breast cancers (BCs) are characterized by the expression of
estrogen receptor alpha (ERα+). ERα acts as ligand-dependent transcription factor for genes …

Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty
years ago as a novel transforming gene. Since its discovery and subsequent pathway …

Context.—The pioneering works on molecular classification (MC) by Perou and Sorlie et al
in the early 2000s using global gene expression profiling identified 5 intrinsic subtypes of …

Background Molecular screening programs use next-generation sequencing (NGS) of
cancer gene panels to analyze metastatic biopsies. We interrogated whether plasma could …

Breast tumors of the basal-like, hormone receptor–negative subtype remain an unmet
clinical challenge, as there is high rate of recurrence and poor survival in patients following …

Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …