The size and surface area of the mammalian brain are thought to be critical determinants of
intellectual ability. Recent studies show that development of the gyrated human neocortex …

Evolutionary expansion and complexification of the primate cerebral cortex are largely
linked to the emergence of the outer subventricular zone (OSVZ), a uniquely structured …

Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and …

Human brain organoid systems offer unprecedented opportunities to investigate both
neurodevelopmental and neurological disease. Single-cell-based transcriptomics or …

Human pluripotent stem cells are a powerful tool for modeling brain development and
disease. The human cortex is composed of two major neuronal populations: projection …

Cortical GABAergic inhibitory interneurons have crucial roles in the development and
function of the cerebral cortex. In rodents, nearly all neocortical interneurons are generated …

GABAergic cortical interneurons underlie the complexity of neural circuits and are
particularly numerous and diverse in humans. In rodents, cortical interneurons originate in …

The most prominent transient compartment of the primate fetal cortex is the deep, cell-
sparse, synapse-containing subplate compartment (SPC). The developmental role of the …

Over a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-
derived neural models has provided substantial data describing neurobiological …