Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

S Toyokuni - Free Radical Biology and Medicine, 2019 - Elsevier
Cancer is the primary cause of human mortality in most countries. This tendency has
increased as various medical therapeutics have advanced, which suggests that we cannot …

Malignant mesothelioma as an oxidative stress-induced cancer: An update

SH Chew, S Toyokuni - Free Radical Biology and Medicine, 2015 - Elsevier
Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively
following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated …

[HTML][HTML] Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre crystal-chemical and physical parameters to the key …

AF Gualtieri - Current research in toxicology, 2021 - Elsevier
Airborne fibres and particularly asbestos represent hazards of great concern for human
health because exposure to these peculiar particulates may cause malignancies such as …

Asbestos conceives Fe (II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama… - Redox Biology, 2020 - Elsevier
Asbestos is still a social burden worldwide as a carcinogen causing malignant
mesothelioma. Whereas recent studies suggest that local iron reduction is a preventive …

Carcinogenesis as side effects of iron and oxygen utilization: from the unveiled truth toward ultimate bioengineering

S Toyokuni, Y Kong, Z Cheng, K Sato, S Hayashi, F Ito… - Cancers, 2020 - mdpi.com
Simple Summary Cancer is a major cause of human mortality worldwide. No life on earth
can live without iron. Persistent oxidative stress resulting from continuous use of iron and …

In vitro acellular dissolution of mineral fibres: A comparative study

AF Gualtieri, S Pollastri, N Bursi Gandolfi… - Scientific Reports, 2018 - nature.com
The study of the mechanisms by which mineral fibres promote adverse effects in both
animals and humans is a hot topic of multidisciplinary research with many aspects that still …

[HTML][HTML] Iron as spirit of life to share under monopoly

S Toyokuni, Y Kong, H Zheng, Y Maeda… - Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
Any independent life requires iron to survive. Whereas iron deficiency causes oxygen
insufficiency, excess iron is a risk for cancer, generating a double-edged sword. Iron …

Iron and thiols as two major players in carcinogenesis: friends or foes?

S Toyokuni - Frontiers in pharmacology, 2014 - frontiersin.org
Iron is the most abundant metal in the human body and mainly works as a cofactor for
proteins such as hemoglobin and various enzymes. No independent life forms on earth can …

An updated evaluation of reported no-observed adverse effect levels for chrysotile, amosite, and crocidolite asbestos for lung cancer and mesothelioma

EM Beckett, A Abelmann, B Roberts… - Critical Reviews in …, 2023 - Taylor & Francis
This analysis updates two previous analyses that evaluated the exposure-response
relationships for lung cancer and mesothelioma in chrysotile-exposed cohorts. We reviewed …

Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells

S Funahashi, Y Okazaki, D Ito, A Asakawa… - Journal of Clinical …, 2015 - jstage.jst.go.jp
抄録 Asbestos exposure is considered a social burden by causing mesothelioma. Despite
the use of synthetic materials, multi-walled carbon nanotubes (MWCNTs) are similar in …