Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

Background The existing estimate of the global burden of latent TB infection (LTBI) as “one-
third” of the world population is nearly 20 y old. Given the importance of controlling LTBI as …

Comprehensive guidelines for treatment of latent tuberculosis infection (LTBI) among
persons living in the United States were last published in 2000 (American Thoracic Society …

Background Rifapentine-based regimens have potent antimycobacterial activity that may
allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis. Methods …

Abstract Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may
develop symptoms and signs of disease (tuberculosis disease) or may have no clinical …

Tuberculosis remains a global health problem with an enormous burden of disease,
estimated at 10.4 million new cases in 2015. To stop the tuberculosis epidemic, it is critical …

Objectives To determine whether BCG vaccination protects against Mycobacterium
tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. Design …

Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …

Running over timescales that span decades or centuries, the epidemiological transition
provides the central narrative of global health. In this transition, a reduction in mortality is …

Rapid expansion of the standardised approach to tuberculosis diagnosis and treatment that
is recommended by WHO allowed more than 36 million people to be cured between 1995 …