DNA helicases involved in DNA repair and their roles in cancer
RM Brosh Jr - Nature Reviews Cancer, 2013 - nature.com
Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …
Their prominence is marked by various cancers and genetic disorders that are linked to …
Replication of G quadruplex DNA
LK Lerner, JE Sale - Genes, 2019 - mdpi.com
A cursory look at any textbook image of DNA replication might suggest that the complex
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …
[HTML][HTML] Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability
VD Paul, R Lill - Biochimica Et Biophysica Acta (BBA)-Molecular Cell …, 2015 - Elsevier
Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita
Dyskeratosis congenita (DC) is an inherited bone marrow failure and cancer predisposition
syndrome caused by aberrant telomere biology. The classic triad of dysplastic nails …
syndrome caused by aberrant telomere biology. The classic triad of dysplastic nails …
Constitutional mutations in RTEL1 cause severe dyskeratosis congenita
Dyskeratosis congenita (DC) and its phenotypically severe variant, Hoyeraal-Hreidarsson
syndrome (HHS), are multisystem bone-marrow-failure syndromes in which the principal …
syndrome (HHS), are multisystem bone-marrow-failure syndromes in which the principal …
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication
JB Vannier, S Sandhu, MIR Petalcorin, X Wu, Z Nabi… - Science, 2013 - science.org
Regulator of telomere length 1 (RTEL1) is an essential DNA helicase that disassembles
telomere loops (T loops) and suppresses telomere fragility to maintain the integrity of …
telomere loops (T loops) and suppresses telomere fragility to maintain the integrity of …
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding
The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to
maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is …
maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is …
The many faces of the helicase RTEL1 at telomeres and beyond
Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …
Replicating through telomeres: a means to an end
P Martínez, MA Blasco - Trends in biochemical sciences, 2015 - cell.com
Proper replication of the telomeric DNA at chromosome ends is critical for preserving
genome integrity. Yet, telomeres present challenges for the replication machinery, such as …
genome integrity. Yet, telomeres present challenges for the replication machinery, such as …
PRMT5 modulates splicing for genome integrity and preserves proteostasis of hematopoietic stem cells
Summary Protein arginine methyltransferase 5 (PRMT5) is essential for hematopoiesis,
while PRMT5 inhibition remains a promising therapeutic strategy against various cancers …
while PRMT5 inhibition remains a promising therapeutic strategy against various cancers …