This review summarizes the mechanisms that control the activity of the c-Myb transcription
factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of …

To better understand endogenous parameters that influence pluripotent cell differentiation
we used human embryonic stem cells (hESCs) as a model system. We demonstrate that …

Abstract Almost 50 years ago, Earl Benditt and his son John described the clonality of the
atherosclerotic plaque. This led Benditt to propose that the atherosclerotic lesion was a …

Background—Myocardin (Myocd) is a strong coactivator that binds the serum response
factor (SRF) transcription factor over CArG elements embedded within smooth muscle cell …

Although it has been observed that aggregate size affects cardiac development, an
incomplete understanding of the cellular mechanisms underlying human pluripotent stem …

Abstract c-Myb is a transcription factor that plays a key role in cell proliferation,
differentiation, and apoptosis. It has been reported that c-Myb is expressed within the …

Background/Aims: Cardiac fibrosis is the primary cause of deteriorated cardiac function in
various cardiovascular diseases. Numerous studies have demonstrated that microRNAs …

The proto-oncogene c-myb (and corresponding nuclear transcription factor, c-Myb)
regulates the proliferation and differentiation of hematologic and vascular smooth muscle …

Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-
stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic …

Introduction MYB is highly expressed in estrogen receptor positive (ER+ ve) breast tumours
and tumour cell lines. We recently demonstrated that MYB is essential for the proliferation of …