New insight into phytochromes: connecting structure to function

J Hughes, A Winkler - Annual review of plant biology, 2024 - annualreviews.org
Red and far-red light–sensing phytochromes are widespread in nature, occurring in plants,
algae, fungi, and prokaryotes. Despite at least a billion years of evolution, their photosensory …

The red edge: bilin-binding photoreceptors as optogenetic tools and fluorescence reporters

K Tang, HM Beyer, MD Zurbriggen… - Chemical …, 2021 - ACS Publications
This review adds the bilin-binding phytochromes to the Chemical Reviews thematic issue
“Optogenetics and Photopharmacology”. The work is structured into two parts. We first …

Ultrafast structural changes direct the first molecular events of vision

T Gruhl, T Weinert, MJ Rodrigues, CJ Milne, G Ortolani… - Nature, 2023 - nature.com
Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors
(GPCRs). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which …

Protein control of photochemistry and transient intermediates in phytochromes

G Salvadori, V Macaluso, G Pellicci, L Cupellini… - Nature …, 2022 - nature.com
Phytochromes are ubiquitous photoreceptors responsible for sensing light in plants, fungi
and bacteria. Their photoactivation is initiated by the photoisomerization of the embedded …

Towards the idea of molecular brains

Y Timsit, SP Grégoire - International Journal of Molecular Sciences, 2021 - mdpi.com
How can single cells without nervous systems perform complex behaviours such as
habituation, associative learning and decision making, which are considered the hallmark of …

Structural snapshot of a bacterial phytochrome in its functional intermediate state

A Schmidt, L Sauthof, M Szczepek, MF Lopez… - Nature …, 2018 - nature.com
Phytochromes are modular photoreceptors of plants, bacteria and fungi that use light as a
source of information to regulate fundamental physiological processes. Interconversion …

Photoreception and signaling in bacterial phytochrome revealed by single-particle cryo-EM

TN Malla, C Hernandez, S Muniyappan… - Science …, 2024 - science.org
Phytochromes are red-light photoreceptors discovered in plants with homologs in bacteria
and fungi that regulate a variety of physiological responses. They display a reversible …

Tips and turns of bacteriophytochrome photoactivation

H Takala, P Edlund, JA Ihalainen… - Photochemical & …, 2020 - pubs.rsc.org
Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction
and movement in plants, fungi and bacteria. Phytochromes switch between two …

High-resolution crystal structures of transient intermediates in the phytochrome photocycle

M Carrillo, S Pandey, J Sanchez, M Noda, I Poudyal… - Structure, 2021 - cell.com
Phytochromes are red/far-red light photoreceptors in bacteria to plants, which elicit a variety
of important physiological responses. They display a reversible photocycle between the …

The structure of Arabidopsis phytochrome A reveals topological and functional diversification among the plant photoreceptor isoforms

ES Burgie, H Li, ZTK Gannam, KE McLoughlin… - Nature plants, 2023 - nature.com
Plants employ a divergent cohort of phytochrome (Phy) photoreceptors to govern many
aspects of morphogenesis through reversible photointerconversion between inactive Pr and …