Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …

Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are
challenging complications of cancer treatment. Many of the major classes of …

Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other
chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia …

Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

Central neuropathic pain (CNP) developing after spinal cord injury (SCI) is described by the
region affected: above-level, at-level and below-level pain occurs in dermatomes rostral …