Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most
common malformations of human structure. The causes of this disorder are heterogeneous …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Autism is a behaviorally defined neurodevelopmental disorder usually diagnosed in early
childhood that is characterized by impairment in reciprocal communication and speech …

The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000
births with almost equal frequencies between two major categories: anencephaly and spina …

Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …

This review attempts to provide a comprehensive overview of the biology of the
physiologically and pharmacologically important transport system termed the “reduced folate …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …