[HTML][HTML] The concept of folic acid in health and disease

Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

[HTML][HTML] Neural tube defects, folic acid and methylation

A Imbard, JF Benoist, HJ Blom - International journal of environmental …, 2013 - mdpi.com
Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

Structural basis for molecular recognition of folic acid by folate receptors

C Chen, J Ke, XE Zhou, W Yi, JS Brunzelle, J Li… - Nature, 2013 - nature.com
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

Spina bifida

LE Mitchell, NS Adzick, J Melchionne, PS Pasquariello… - The Lancet, 2004 - thelancet.com
Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most
common malformations of human structure. The causes of this disorder are heterogeneous …

[HTML][HTML] Folate and human reproduction

T Tamura, MF Picciano - The American journal of clinical nutrition, 2006 - Elsevier
The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

SJ James, S Melnyk, S Jernigan… - American Journal of …, 2006 - Wiley Online Library
Autism is a behaviorally defined neurodevelopmental disorder usually diagnosed in early
childhood that is characterized by impairment in reciprocal communication and speech …

Epidemiologic and genetic aspects of spina bifida and other neural tube defects

KS Au, A Ashley‐Koch… - Developmental disabilities …, 2010 - Wiley Online Library
The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000
births with almost equal frequencies between two major categories: anencephaly and spina …

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

R Zhao, LH Matherly, ID Goldman - Expert reviews in molecular …, 2009 - cambridge.org
Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …

Human reduced folate carrier: translation of basic biology to cancer etiology and therapy

LH Matherly, Z Hou, Y Deng - Cancer and metastasis reviews, 2007 - Springer
This review attempts to provide a comprehensive overview of the biology of the
physiologically and pharmacologically important transport system termed the “reduced folate …

Epidemiology of neural tube defects

LE Mitchell - American Journal of Medical Genetics Part C …, 2005 - Wiley Online Library
The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …