Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Lactate (La−) has long been at the center of controversy in research, clinical, and athletic
settings. Since its discovery in 1780, La− has often been erroneously viewed as simply a …

The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …

Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as …

The energy requirements of the brain are very high, and tight regulatory mechanisms
operate to ensure adequate spatial and temporal delivery of energy substrates in register …

More than two hundred years after its discovery, lactate still remains an intriguing molecule.
Considered for a long time as a waste product of metabolism and the culprit behind …

Glycogen metabolism has important implications for the functioning of the brain, especially
the cooperation between astrocytes and neurons. According to various research data, in a …