The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Musculoskeletal pain due to ischemia is present in a variety of clinical conditions including
peripheral vascular disease (PVD), sickle cell disease (SCD), complex regional pain …

To what extent dorsal horn interneurons contribute to the modality specific processing of
pain and itch messages is not known. Here, we report that loxp/cre-mediated CNS deletion …

Unresolved inflammation is a significant predictor for developing chronic pain, and targeting
the mechanisms underlying inflammation offers opportunities for therapeutic intervention …

Trigeminal (TG) pain often lacks a satisfactory pharmacological control. A better
understanding of the molecular cross‐talk between TG neurons and surrounding satellite …

Millions of individuals worldwide suffer from acute and, more severely, chronic pain
conditions (eg, neuropathic pain, and migraine). The latter bear tremendous personal …

Gut homeostasis results from complex neuro-immune interactions aimed at triggering
stereotypical and specific programs of coordinated mucosal secretion and powerful motor …

To facilitate analyses of purinergic signaling in peripheral nerve glia, we review recent
literature and catalog purinergic receptor mRNA expression in cultured mouse Schwann …

Purinergic signaling system plays a pivotal role in the trigeminal ganglion (TG) which is a
primary sensory tissue in vertebrate nervous systems involving orofacial nociception and …

Although activation of astrocytes is critical in developing neuropathic pain (NP) following
nerve injury, the underlying mechanisms of NP and therapeutic management for NP are still …