Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS

G Natale, F Limanaqi, CL Busceti… - Frontiers in …, 2021 - frontiersin.org
The classic concept of the absence of lymphatic vessels in the central nervous system
(CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was …

Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

HK Alajangi, M Kaur, A Sharma, S Rana, S Thakur… - Molecular Brain, 2022 - Springer
The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I—anatomy and physiology

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …

Impaired glymphatic and meningeal lymphatic functions in patients with chronic migraine

CH Wu, FC Chang, YF Wang, JF Lirng… - Annals of …, 2024 - Wiley Online Library
Objective This study was undertaken to investigate migraine glymphatic and meningeal
lymphatic vessel (mLV) functions. Methods Migraine patients and healthy controls (HCs) …

The glymphatic system: a review of the challenges in visualizing its structure and function with MR imaging

S Naganawa, T Taoka - Magnetic Resonance in Medical Sciences, 2022 - jstage.jst.go.jp
The central nervous system (CNS) was previously thought to be the only organ system
lacking lymphatic vessels to remove waste products from the interstitial space. Recently …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Systematic review of magnetic resonance lymphangiography from a technical perspective

M Mills, M van Zanten, M Borri… - Journal of Magnetic …, 2021 - Wiley Online Library
Background Clinical examination and lymphoscintigraphy are the current standard for
investigating lymphatic function. Magnetic resonance imaging (MRI) facilitates three …

High‐density lipoprotein‐related cholesterol metabolism in Alzheimer's disease

S Pedrini, P Chatterjee, E Hone… - Journal of …, 2021 - Wiley Online Library
High‐density lipoproteins (HDL) are a heterogeneous class of molecules whose main
function is to remove excess cholesterol through a mechanism called reverse transport, in …

High-frequency ultrasound imaging for monitoring the function of meningeal lymphatic system in mice

O Mee-Inta, CF Hsieh, DQ Chen, CH Fan, YY Chiang… - Ultrasonics, 2023 - Elsevier
The meningeal lymphatic system drains the cerebrospinal fluid from the subarachnoid space
to the cervical lymphatic system, primarily to the deep cervical lymph nodes. Perturbations of …