Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs

MA Tantawy, MS Nafie, GA Elmegeed, IAI Ali - Bioorganic chemistry, 2017 - Elsevier
Steroids are polycyclic compounds that have a wide range of biological activities. They are
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …

Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid

MM Hammouda, KM Elattar, MM Rashed, AMA Osman - Steroids, 2023 - Elsevier
Reports on structural modification of heterosteroids through various reactions, and
developed synthetic routes have considerably increased over the last decade. The present …

Steroidal pyrimidines and dihydrotriazines as novel classes of anticancer agents against hormone-dependent breast cancer cells

AM Scherbakov, AV Komkov… - Frontiers in …, 2018 - frontiersin.org
Most breast and prostate tumors are hormone-dependent, making it possible to use
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …

Fe (iii)-Catalyzed synthesis of steroidal imidazoheterocycles as potent antiproliferative agents

S Samanta, AK Ghosh, S Ghosh, AA Ilina… - Organic & …, 2020 - pubs.rsc.org
An efficient and practical method has been developed for the synthesis of steroidal
imidazoheterocycles via cost-effective and environmentally benign FeCl3-catalyzed …

Discovery of highly potent proapoptotic antiestrogens in a series of androst-5, 16-dienes D-modified with imidazole-annulated pendants

V Birukova, A Scherbakov, A Ilina, D Salnikova… - The Journal of Steroid …, 2023 - Elsevier
Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …

Novel steroidal 1, 3, 4-thiadiazines: Synthesis and biological evaluation in androgen receptor-positive prostate cancer 22Rv1 cells

AS Komendantova, AM Scherbakov, AV Komkov… - Bioorganic …, 2019 - Elsevier
A flexible approach to previously unknown spirofused and linked 1, 3, 4-thiadiazine
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …

Design, synthesis, and biological evaluation of imidazopyridine‐linked thiazolidinone as potential anticancer agents

MA Iqbal, A Husain, O Alam, SA Khan… - Archiv der …, 2020 - Wiley Online Library
In this study, two series of imidazopyridine‐linked thiazolidinone rings (5a–h and 6a–h)
constituting 16 new compounds were synthesized and tested for their antiproliferative …

Synthesis of Imidazo[2,1-b]thiazoles via Copper-Catalyzed A3-Coupling in Batch and Continuous Flow

IV Rassokhina, TA Tikhonova… - The Journal of …, 2017 - ACS Publications
A straightforward method for the synthesis of functionalized imidazo [2, 1-b] thiazoles starting
from benzaldehydes, 2-aminothiazoles, and alkynes under copper (I, II) catalysis was …

Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

CS Rani, AG Reddy, E Susithra, KK Mak… - Medicinal Chemistry …, 2021 - Springer
A novel series of amide functionalized imidazo [1, 2-a] pyridine (14a–14j) derivatives were
synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB …

Difluoroborate complexes in the synthesis of heterocyclic (13α)-estrone derivatives modified at the A-ring

AA Sukhanova, MA Prezent, AN Fakhrutdinov… - Russian Chemical …, 2023 - Springer
An efficient synthesis of (13α)-estrone derivatives containing pyran, isoxazole, or pyrazole
moieties on the A-ring was performed based on difluoroborate complexes using the chelate …