Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs
Steroids are polycyclic compounds that have a wide range of biological activities. They are
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid
MM Hammouda, KM Elattar, MM Rashed, AMA Osman - Steroids, 2023 - Elsevier
Reports on structural modification of heterosteroids through various reactions, and
developed synthetic routes have considerably increased over the last decade. The present …
developed synthetic routes have considerably increased over the last decade. The present …
Steroidal pyrimidines and dihydrotriazines as novel classes of anticancer agents against hormone-dependent breast cancer cells
AM Scherbakov, AV Komkov… - Frontiers in …, 2018 - frontiersin.org
Most breast and prostate tumors are hormone-dependent, making it possible to use
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …
Fe (iii)-Catalyzed synthesis of steroidal imidazoheterocycles as potent antiproliferative agents
An efficient and practical method has been developed for the synthesis of steroidal
imidazoheterocycles via cost-effective and environmentally benign FeCl3-catalyzed …
imidazoheterocycles via cost-effective and environmentally benign FeCl3-catalyzed …
Discovery of highly potent proapoptotic antiestrogens in a series of androst-5, 16-dienes D-modified with imidazole-annulated pendants
V Birukova, A Scherbakov, A Ilina, D Salnikova… - The Journal of Steroid …, 2023 - Elsevier
Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
Novel steroidal 1, 3, 4-thiadiazines: Synthesis and biological evaluation in androgen receptor-positive prostate cancer 22Rv1 cells
AS Komendantova, AM Scherbakov, AV Komkov… - Bioorganic …, 2019 - Elsevier
A flexible approach to previously unknown spirofused and linked 1, 3, 4-thiadiazine
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …
Design, synthesis, and biological evaluation of imidazopyridine‐linked thiazolidinone as potential anticancer agents
In this study, two series of imidazopyridine‐linked thiazolidinone rings (5a–h and 6a–h)
constituting 16 new compounds were synthesized and tested for their antiproliferative …
constituting 16 new compounds were synthesized and tested for their antiproliferative …
Synthesis of Imidazo[2,1-b]thiazoles via Copper-Catalyzed A3-Coupling in Batch and Continuous Flow
IV Rassokhina, TA Tikhonova… - The Journal of …, 2017 - ACS Publications
A straightforward method for the synthesis of functionalized imidazo [2, 1-b] thiazoles starting
from benzaldehydes, 2-aminothiazoles, and alkynes under copper (I, II) catalysis was …
from benzaldehydes, 2-aminothiazoles, and alkynes under copper (I, II) catalysis was …
Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines
CS Rani, AG Reddy, E Susithra, KK Mak… - Medicinal Chemistry …, 2021 - Springer
A novel series of amide functionalized imidazo [1, 2-a] pyridine (14a–14j) derivatives were
synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB …
synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB …
Difluoroborate complexes in the synthesis of heterocyclic (13α)-estrone derivatives modified at the A-ring
AA Sukhanova, MA Prezent, AN Fakhrutdinov… - Russian Chemical …, 2023 - Springer
An efficient synthesis of (13α)-estrone derivatives containing pyran, isoxazole, or pyrazole
moieties on the A-ring was performed based on difluoroborate complexes using the chelate …
moieties on the A-ring was performed based on difluoroborate complexes using the chelate …