Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …

Aims Circular RNA (circRNA) is a newly validated class of single-stranded RNA,
ubiquitously expressed in mammalian tissues and possessing key functions including acting …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …

Abstract CDK4 inhibitors (CDK4i) earned Breakthrough Therapy Designation from the FDA
last year and are entering phase III clinical trials in several cancers. However, not all tumors …

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired
proteasomal function appears to contribute to heart disease. Specific proteasomal …

The emergence of mitochondria as critical regulators of cardiac myocyte survival and death
has revolutionized the field of cardiac biology. Indeed, it is now well recognized that …

The assembly and maintenance of the cardiac sarcomere, which contains the basic
contractile components of actin and myosin, are essential for cardiac function. While often …

Aims The molecular mechanisms that regulate cardiomyocyte apoptosis and their role in
human heart failure (HF) are uncertain. Expression of the apoptosis regulator p53 is …

Gastric cancer remains the second leading cause of cancer deaths worldwide. Resistance to
chemotherapy is a significant barrier for effective cancer treatment. Here, we identified miR …