Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic
interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical …

The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Background: Sodium-glucose cotransporter-2 inhibitors are foundational therapy in patients
with heart failure with reduced ejection fraction (HFrEF), but underlying mechanisms of …

Background: The failing heart is energy starved with impaired oxidation of long-chain fatty
acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Over the last decade, studies suggested that dietary behavior modification, including fasting,
can improve metabolic and cardiovascular markers as well as body composition. Given the …

Background: Defects in energetics are thought to be central to the pathophysiology of
hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known …