A delightful trip along the pathway of cannabinoid and endocannabinoid chemistry and pharmacology
R Mechoulam - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
After a traumatic childhood in Europe during the Second World War, I found that scientific
research in Israel was a pleasure beyond my expectations. Over the last 65 year, I have …
research in Israel was a pleasure beyond my expectations. Over the last 65 year, I have …
[HTML][HTML] Cannabinoids as multifaceted compounds
Since ancient times, Cannabis and its preparations have found various applications such as
for medical, recreational and industrial purposes. Subsequently the 1930s, legislation in …
for medical, recreational and industrial purposes. Subsequently the 1930s, legislation in …
The cytotoxic effects of cannabidiol and cannabigerol on glioblastoma stem cells may mostly involve GPR55 and TRPV1 signalling
TT Lah, B Majc, M Novak, A Sušnik, B Breznik… - Cancers, 2022 - mdpi.com
Simple Summary In glioblastoma (GBM), the highest-grade IV glioma, members of the large
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …
Tetrahydrocannabinols: Potential cannabimimetic agents for cancer therapy
P Prateeksha, VK Sharma, SM Singh… - Cancer and Metastasis …, 2023 - Springer
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose
signaling to the endocannabinoid system is essential for controlling cell survival and …
signaling to the endocannabinoid system is essential for controlling cell survival and …
In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol and Cannabidiol-Rich Extract
P Śledziński, A Nowak-Terpiłowska, P Rzymski… - Molecules, 2023 - mdpi.com
Plant cannabinoids, secondary metabolites of species belonging to the Cannabis genus,
can mimic the endocannabinoids' action and exert biological effects. Considering the …
can mimic the endocannabinoids' action and exert biological effects. Considering the …
Targeting the Endocannabinoid System Present in the Glioblastoma Tumour Microenvironment as a Potential Anti-Cancer Strategy
The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion
among adult-type diffuse gliomas, representing the most common primary brain tumour in …
among adult-type diffuse gliomas, representing the most common primary brain tumour in …
Cannabinoid Combination Targets NOTCH1-Mutated T-ALL Through the Integrated Stress Response Pathway
In T-cell acute lymphoblastic leukemia (T-ALL) more than 50% of cases display
autoactivation of Notch1 signaling, leading to oncogenic transformation. We have previously …
autoactivation of Notch1 signaling, leading to oncogenic transformation. We have previously …
Investigating chemopreventive and chemotherapeutic applications of cannabinoids in prostate cancer
E O'Reilly - 2022 - researchrepository.ucd.ie
Prostate cancer is the 5th leading cause of cancer death in men, responsible for more than
375,000 deaths worldwide in 2020. For patients with localised prostate cancer, the 5-year …
375,000 deaths worldwide in 2020. For patients with localised prostate cancer, the 5-year …