The pancreatic cancer genome revisited

A Hayashi, J Hong… - … reviews Gastroenterology & …, 2021 - nature.com
Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …

[HTML][HTML] Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis

M Chang, W Chen, R Xia, Y Peng, P Niu, H Fan - Molecules, 2023 - mdpi.com
Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …

[HTML][HTML] The relationship between acute and chronic pancreatitis with pancreatic adenocarcinoma

T Alhobayb, R Peravali, M Ashkar - Diseases, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading
to significant cancer-related mortality and an overall five-year survival rate of about nine …

Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly

N Amruta, AA Rahman, E Pinteaux, G Bix - Journal of neuroimmunology, 2020 - Elsevier
Stroke is the leading cause of death and the main cause of disability in surviving patients.
The detrimental interaction between immune cells, glial cells, and matrix components in …

[HTML][HTML] Vitamin D: a potential star for treating chronic pancreatitis

M Zheng, R Gao - Frontiers in Pharmacology, 2022 - frontiersin.org
Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The
incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is …

[HTML][HTML] Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds

Y Wu, C Zhang, M Guo, W Hu, Y Qiu, M Li… - Frontiers in …, 2022 - frontiersin.org
Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal
adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is …

[HTML][HTML] Heterogeneous changes in gut and tumor microbiota in patients with pancreatic cancer: insights from clinical evidence

F Zhao, A Chen, X Wu, X Deng, J Yang, J Xue - BMC cancer, 2024 - Springer
Background Pancreatic cancer is the foremost contributor to cancer-related deaths globally,
and its prevalence continues to rise annually. Nevertheless, the underlying mechanisms …

Retinoic acid signaling pathway in pancreatic stellate cells: Insight into the anti-fibrotic effect and mechanism

L Sun, M Zheng, Y Gao, DR Brigstock, R Gao - European Journal of …, 2024 - Elsevier
Pancreatic stellate cells (PSCs) are activated following loss of cytoplasmic vitamin A (retinol)-
containing lipid droplets, which is a key event in the process of fibrogenesis of chronic …

[HTML][HTML] The role of adipokines in pancreatic cancer

Q Wang, H Wang, Y Ding, M Wan, M Xu - Frontiers in Oncology, 2022 - frontiersin.org
In modern society, inappropriate diets and other lifestyle habits have made obesity an
increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive …

[HTML][HTML] Risk factors associated with pancreatic cancer in the UK Biobank Cohort

TM Ke, A Lophatananon, KR Muir - Cancers, 2022 - mdpi.com
Simple Summary The study explored pancreatic cancer (PaCa) risk factors in the UK
Biobank cohort. The risk factors included non-modifiable risk factors: age, gender, and …