The role of the vascular endothelium in progressive renal disease is not well understood.
This review presents evidence that progressive renal disease is characterized by a …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Overproduction of transforming growth factor-β clearly underlies tissue fibrosis in numerous
experimental and human diseases. Transforming growth factor-β's powerful fibrogenic …

A prevention protocol has demonstrated that bone morphogenetic protein-7 (BMP-7) blunted
the development of fibrosis in a rat model of unilateral ureteral obstruction. This prevention …

The renal community is faced with an ever increasing number of patients reaching end-
stage renal failure. Clinical studies have provided clear evidence that angiotensin …

Unilateral ureteral obstruction (UUO) is a model of renal injury characterized by progressive
tubulointerstitial fibrosis and renal damage, while relatively sparing the glomerulus and not …

Transforming growth factor-beta (TGF-beta) and the renin-angiotensin system (RAS) have
both been implicated in the pathogenesis of glomerulosclerosis in diabetic kidney disease …

Studies have demonstrated that local angiotensin II (Ang II) generation is enhanced in
repairing kidney and that ACE inhibition or AT1 receptor blockade attenuates renal fibrosis …

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases
the underlying aetiology is unknown, but the most frequently reported pathological diagnosis …