Osteocytes and Primary Cilia

SW Verbruggen, A Sittichokechaiwut… - Current Osteoporosis …, 2023 - Springer
Abstract Purpose of Review The purpose of this review is to provide a background on
osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing …

All the might of the osteocyte: emerging roles in chronic kidney disease

LV Albrecht, RC Pereira, IB Salusky - Kidney international, 2023 - Elsevier
Osteocytes are the most abundant type of bone cell and play crucial roles in bone health.
Osteocytes sense mechanical stress and orchestrate osteoblasts and osteoclasts to …

Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy

M Martinez-Calle, G Courbon… - The Journal of …, 2023 - Am Soc Clin Investig
Renal osteodystrophy (ROD) is a disorder of bone metabolism that affects virtually all
patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes …

[HTML][HTML] Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

T Cheng, A Mariappan, E Langner, K Shim… - JCI insight, 2024 - ncbi.nlm.nih.gov
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder
accounting for approximately 5% of patients with renal failure, yet therapeutics for the …

Bone and bone derived factors in kidney disease

P Simic - Frontiers in Physiology, 2024 - frontiersin.org
Purpose of review: Mineral and bone disorder (MBD) is a prevalent complication in chronic
kidney disease (CKD), significantly impacting overall health with multifaceted implications …

Autosomal Dominant Polycystic Kidney Disease: Extrarenal Involvement

M Righini, R Mancini, M Busutti, A Buscaroli - International Journal of …, 2024 - mdpi.com
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary
kidney disorder, but kidneys are not the only organs involved in this systemic disorder …

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H Chen, V Shi, S Wang, L Sun… - Biological …, 2018 - digitalcommons.wustl.edu
Neurosteroids are endogenous sterols that potentiate or inhibit pentameric ligand-gated ion
channels (pLGICs) and can be effective anesthetics, analgesics, or anti-epileptic drugs. The …