It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Significance: Oxygen and circadian rhythmicity are essential in a myriad of physiological
processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to …

Abstract Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene
that plays an important regulatory role in detoxification, anti‑oxidative damage, and the …

Background Data on genetic susceptibility to sporadic gastric carcinoma have been
published at a growing pace, but to date no comprehensive overview and quantitative …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

There is substantial agreement that the unbalance between oxidant and antioxidant species
may affect the onset and/or the course of a number of common diseases including …

Exposure to environmental hazards has been associated with diseases in humans. The
identification of single nucleotide polymorphisms (SNPs) in human populations exposed to …

Glutathione S-transferase π (GSTπ) is a Phase II metabolic enzyme that is an important
facilitator of cellular detoxification. Traditional dogma asserts that GSTπ functions to catalyze …

Some mammalian tissues uniquely concentrate carotenoids, but the underlying biochemical
mechanism for this accumulation has not been fully elucidated. For instance, the central …

Prenatal ethanol exposure (PNEE) causes long-lasting deficits in brain structure and
function. In this study, we have examined the effect of PNEE on antioxidant capacity and …