Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central
nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different …

The ability of vertebrates to regenerate amputated appendages is increasingly well-
understood at the cellular level. Cells mediating an innate immune response and …

The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network
of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular …

Heparin (HP) and heparan sulfate (HS) play important roles in many biological events.
Increasing evidence has shown that the biological functions of HP and HS can be critically …

The increasing cost of high-volume cultures and dependence on serum and growth factor
supplementation limit the affordability of mesenchymal stromal cell (MSC) therapies. This …

Objective Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common
phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and …

Heparan sulfate (HS) is a component of cell surface and extracellular matrix proteoglycans
that regulates numerous signaling pathways by binding and activating multiple growth …

The implementation of efficient strategies for cellular delivery is the most significant hurdle in
the development of oligonucleotide and protein-based nanomedicines. Unlike small …

The interaction between glycosaminoglycans (GAGs) and proteins is important for the
regulation of protein transport and activity. Here we present a novel method for the …

Cellular senescence is considered as an important tumor-suppressive mechanism. Here, we
demonstrated that heparan sulfate (HS) prevents cellular senescence by fine-tuning of the …