Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast
cancer, and that 41,400 will die from it. Since breast cancers often become resistant to …

The protein folding capacity of the endoplasmic reticulum (ER) is tightly regulated by a
network of signaling pathways, known as the unfolded protein response (UPR). UPR …

The unfolded protein response (UPR) is activated when unfolded proteins accumulate in the
endoplasmic reticulum (ER). The basic mechanism of the UPR in maintaining ER …

The endoplasmic reticulum (ER) is central to the processing of luminal, transmembrane, and
secretory proteins, and maintaining a functional ER is essential for organismal physiology …

Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER
stress, eukaryotic cells commonly provoke a protective gene expression program called the …

Since its discovery more than 25 years ago, great progress has been made in our
understanding of the unfolded protein response (UPR), a homeostatic mechanism that …

In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a
large transcriptional program to increase ER folding capacity. During the budding yeast …

Hac1p is a key transcription factor regulating the unfolded protein response (UPR) induced
by abnormal accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) …

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor growth and
aggressiveness. Endoplasmic Reticulum (ER) stress has been documented in most major …