Sex matters: a comprehensive comparison of female and male hearts

SR St. Pierre, M Peirlinck, E Kuhl - Frontiers in physiology, 2022 - frontiersin.org
Cardiovascular disease in women remains under-diagnosed and under-treated. Recent
studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic …

Sex and gender differences in myocarditis and dilated cardiomyopathy: an update

DL Fairweather, DJ Beetler, N Musigk… - Frontiers in …, 2023 - frontiersin.org
In the past decade there has been a growing interest in understanding sex and gender
differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review …

[HTML][HTML] hERG K+ channels: structure, function, and clinical significance

JI Vandenberg, MD Perry, MJ Perrin… - Physiological …, 2012 - journals.physiology.org
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Basic notions of heart rate variability and its clinical applicability

LCM Vanderlei, CM Pastre, RA Hoshi… - Brazilian Journal of …, 2009 - SciELO Brasil
Autonomic nervous system (ANS) plays an important role in the regulation of the
physiological processes of the human organism during normal and pathological conditions …

[HTML][HTML] Noções básicas de variabilidade da frequência cardíaca e sua aplicabilidade clínica

LCM Vanderlei, CM Pastre, RA Hoshi… - Brazilian Journal of …, 2009 - SciELO Brasil
O sistema nervoso autônomo (SNA) desempenha um papel importante na regulação dos
processos fisiológicos do organismo humano tanto em condições normais quanto …

The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias

MJ Curtis, JC Hancox, A Farkas, CL Wainwright… - Pharmacology & …, 2013 - Elsevier
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women

F Franconi, I Campesi - British journal of pharmacology, 2014 - Wiley Online Library
Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …

Molecular pathophysiology of congenital long QT syndrome

MS Bohnen, G Peng, SH Robey… - Physiological …, 2017 - journals.physiology.org
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Gender differences in clinical manifestations of Brugada syndrome

B Benito, A Sarkozy, L Mont, S Henkens… - Journal of the American …, 2008 - jacc.org
Objectives: We sought to assess differences in phenotype and prognosis between men and
women in a large population of patients with Brugada syndrome. Background: A male …

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

JC Hancox, MJ McPate, A El Harchi… - Pharmacology & …, 2008 - Elsevier
Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …