Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets
V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications
Y Dwivedi - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Major depressive disorder (MDD) is a major public health concern. Despite tremendous
advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a …
advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a …
Neurobiology of major depressive disorder
R Villanueva - Neural plasticity, 2013 - Wiley Online Library
We survey studies which relate abnormal neurogenesis to major depressive disorder.
Clinically, descriptive gene and protein expression analysis and genetic and functional …
Clinically, descriptive gene and protein expression analysis and genetic and functional …
MicroRNA-dependent control of neuroplasticity in affective disorders
HC Martins, G Schratt - Translational Psychiatry, 2021 - nature.com
Affective disorders are a group of neuropsychiatric disorders characterized by severe mood
dysregulations accompanied by sleep, eating, cognitive, and attention disturbances, as well …
dysregulations accompanied by sleep, eating, cognitive, and attention disturbances, as well …
Brain-derived neurotrophic factor and antidepressive effect of electroconvulsive therapy: systematic review and meta-analyses of the preclinical and clinical literature
M Polyakova, ML Schroeter, BM Elzinga, S Holiga… - PLoS one, 2015 - journals.plos.org
Emerging data suggest that Electro-Convulsive Treatment (ECT) may reduce depressive
symptoms by increasing the expression of Brain-Derived Neurotrophic Factor (BDNF). Yet …
symptoms by increasing the expression of Brain-Derived Neurotrophic Factor (BDNF). Yet …
Circulating microRNAs as biomarkers for depression: many candidates, few finalists
Background Recent research has highlighted the potential of microRNAs to serve as
physiological indicators of disease process among clinically depressed patients. Methods In …
physiological indicators of disease process among clinically depressed patients. Methods In …
MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective
MA Ortega, MA Alvarez-Mon, C García-Montero… - Biomedicines, 2021 - mdpi.com
Major Depressive Disorder (MDD) represents a major global health concern, a body-mind
malady of rising prevalence worldwide nowadays. The complex network of mechanisms …
malady of rising prevalence worldwide nowadays. The complex network of mechanisms …
CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system
MF Song, JZ Dong, YW Wang, J He, X Ju… - Journal of affective …, 2015 - Elsevier
Background Animal and cell line studies demonstrated that miR-16 may be associated with
major depressive disorder (MDD) via regulation of the expression of serotonin transporter …
major depressive disorder (MDD) via regulation of the expression of serotonin transporter …
Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre-and post-treatment patients with major depressive disorder
S He, X Liu, K Jiang, D Peng, W Hong, Y Fang… - Journal of psychiatric …, 2016 - Elsevier
Recently, increasing evidence has indicated that dysfunction of microRNA-124 (miR-124)
might be involved in the pathophysiology and treatment of major depressive disorder (MDD) …
might be involved in the pathophysiology and treatment of major depressive disorder (MDD) …
Sex‐specific disruptions in spatial memory and anhedonia in a “two hit” rat model correspond with alterations in hippocampal brain‐derived neurotrophic factor …
Post‐mortem studies have demonstrated reduced expression of brain‐derived neurotrophic
factor (BDNF) in the hippocampus of schizophrenia and major depression patients. The “two …
factor (BDNF) in the hippocampus of schizophrenia and major depression patients. The “two …