Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

The evolution of body shape is thought to be tightly coupled to changes in regulatory
sequences, but specific molecular events associated with major morphological transitions in …

A core question in evolutionary biology is whether convergent phenotypic evolution is driven
by convergent molecular changes in proteins or regulatory regions. We combined …

The limb is a commonly used model system for developmental biology. Given the need for
precise control of complex signalling pathways to achieve proper patterning, the limb is also …

TBX5 is a member of the T-box transcription factor family and is primarily known for its role in
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …

The myriad developmental roles served by the T-box family of transcription factor genes defy
easy categorization. Present in all metazoans, the T-box genes are involved in early …

A critical question in biology is how new traits evolve, but studying this in wild animals
remains challenging. Here, we probe the genetic basis of trait gain in sea robin fish, which …

Since their discovery Hox genes have been at the core of the established models explaining
the development and evolution of the vertebrate body plan as well as its paired …

The tetrapod forelimb and hindlimb are serially homologous structures that share a broad
range of developmental pathways responsible for their patterning and outgrowth …