Experimental models to study intestinal microbes–mucus interactions in health and disease

L Etienne-Mesmin, B Chassaing… - FEMS microbiology …, 2019 - academic.oup.com
ABSTRACT A close symbiotic relationship exists between the intestinal microbiota and its
host. A critical component of gut homeostasis is the presence of a mucus layer covering the …

Adhesion properties of lactic acid bacteria on intestinal mucin

K Nishiyama, M Sugiyama, T Mukai - Microorganisms, 2016 - mdpi.com
Lactic acid bacteria (LAB) are Gram-positive bacteria that are natural inhabitants of the
gastrointestinal (GI) tracts of mammals, including humans. Since Mechnikov first proposed …

Synthetic biology approaches to engineer probiotics and members of the human microbiota for biomedical applications

JR Bober, CL Beisel, NU Nair - Annual review of biomedical …, 2018 - annualreviews.org
An increasing number of studies have strongly correlated the composition of the human
microbiota with many human health conditions and, in several cases, have shown that …

Lactobacillus Cell Surface Proteins Involved in Interaction with Mucus and Extracellular Matrix Components

L Muscariello, B De Siena, R Marasco - Current Microbiology, 2020 - Springer
The gut microbiota is a complex microbial ecosystem where bacteria, through mutual
interactions, cooperate in maintaining of wellbeing and health. Lactobacilli are among the …

Tripartite relationship between gut microbiota, intestinal mucus and dietary fibers: towards preventive strategies against enteric infections

T Sauvaitre, L Etienne-Mesmin… - FEMS Microbiology …, 2021 - academic.oup.com
The human gut is inhabited by a large variety of microorganims involved in many
physiological processes and collectively referred as to gut microbiota. Disrupted microbiome …

Lactobacillus reuteri Inhibition of Enteropathogenic Escherichia coli Adherence to Human Intestinal Epithelium

ADS Walsham, DA MacKenzie, V Cook… - Frontiers in …, 2016 - frontiersin.org
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal infant death in
developing countries, and probiotic bacteria have been shown to provide health benefits in …

Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors

KP Bene, DW Kavanaugh, C Leclaire… - Frontiers in …, 2017 - frontiersin.org
The vertebrate gut symbiont Lactobacillus reuteri exhibits strain-specific adhesion and
health-promoting properties. Here, we investigated the role of the mucus adhesins, CmbA …

Structural insights into bacterial recognition of intestinal mucins

S Etzold, N Juge - Current opinion in structural biology, 2014 - Elsevier
Highlights•Diversity of mucin glycans along the GI tract offers numerous recognition sites for
gut bacteria.•Commensal and pathogenic bacteria have evolved adhesins with …

Mechanistic insights into the host-microbe interaction and pathogen exclusion mediated by the Mucus-binding protein of Lactobacillus plantarum

KS Singh, S Kumar, AK Mohanty, S Grover… - Scientific reports, 2018 - nature.com
Surface adhesins of pathogens and probiotics strains are implicated in mediating the
binding of microbes to host. Mucus-binding protein (Mub) is unique to gut inhabiting lactic …

Quantifying and engineering mucus adhesion of probiotics

ZJS Mays, TC Chappell, NU Nair - ACS synthetic biology, 2020 - ACS Publications
Mucus in the gastrointestinal (GI) tract is the primary point-of-interaction between humans
and their gut microbiota. This intimates that mucus not only ensures protection against …