The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general
population, as is detected in about one third of patients with nonalcoholic fatty liver disease …

We report∼ 17.6 million genetic variants from whole-genome sequencing of 2,120
Sardinians; 22% are absent from previous sequencing-based compilations and are …

Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of
hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can …

Background—Increased iron store has been linked to risk of cardiovascular disease.
Structural alterations of arteries in β-thalassemia major patients and in vitro functional …

Thalassemia intermedia (TI), also known as nontransfusion dependent thalassemia (NTDT),
is a type of thalassemia where affected patients do not require lifelong regular transfusions …

Blood transfusion can be a life-saving therapy for β-thalassemia major and β-
thalassemia/HbE (β-TM) patients with chronic anemia, major caused severe iron overload …

BACKGROUND: Beta-thalassemia major is associated with increased cardiovascular risk,
although the underlying mechanisms remain unclear. We examined endothelial function …

BACKGROUND: Beta-thalassemia is considered to be the most frequent hereditary blood
disorder worldwide. Lipid abnormalities have been detected in different types of beta …

Abstract β-Thalassemia (β-thal) is a genetic disorder, representing a major health problem in
Algeria. It is associated with altered lipid levels and a state of oxidative stress that can lead …

Objectives: In this study, we aimed to investigate the relationship between chronic hemolysis
and increased body iron burden with development of premature atherosclerosis by carotid …