Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Importance Although clinical trials demonstrate the superior effectiveness of medication for
opioid use disorder (MOUD) compared with nonpharmacologic treatment, national data on …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use | New England
Journal of Medicine Skip to main content Access provided byTE WHATU ORA HEALTH NEW …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Learning Objective: After participating in this activity, learners should be better able to:
Evaluate the rationale for and current evidence supporting medication-assisted treatment of …

Background Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual
buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and …

Opioid use and overdose rates have risen to epidemic levels in the United States during the
past decade. Fortunately, there are effective medications (ie, methadone, buprenorphine …