Survivin: A molecular biomarker in cancer

PK Jaiswal, A Goel, RD Mittal - Indian Journal of Medical …, 2015 - journals.lww.com
Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases
and blocks cell death, is highly expressed in most cancers and is associated with a poor …

Inhibitors of apoptosis: clinical implications in cancer

MS Mohamed, MK Bishr, FM Almutairi, AG Ali - Apoptosis, 2017 - Springer
Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma

Z Khan, AA Khan, H Yadav, GBKS Prasad… - Cellular & molecular …, 2017 - Springer
Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of
locally advanced disease generally requires various combinations of radiotherapy, surgery …

The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

A Rafatmanesh, M Behjati, N Mobasseri… - Journal of Cellular …, 2020 - Wiley Online Library
Survivin is a member of the family of apoptosis inhibitory proteins with increased expression
level in most cancerous tissues. Evidence shows that survivin plays regulatory roles in …

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

I Mumlek, P Ozretić, M Sabol, M Leović… - International journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma
(OPSCC) are the most common types of cancers in the head and neck region (HNSCC) …

An insight into Survivin in relevance to hematological, biochemical and genetic characteristics in tobacco chewers with oral squamous cell carcinoma

ST Yesupatham, CD Dayanand… - Cells, 2023 - mdpi.com
Background: Survivin is an inhibitor of apoptosis protein (IAP), encoded by the Baculoviral
IAP Repeat Containing 5 (BIRC5) gene located on q arm (25.3) on chromosome 17. It is …

Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

X Fang, X Cao, J Xiao, Y Hu, M Chen… - Journal of Drug …, 2024 - Taylor & Francis
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP)
family due to its predominant expression in tumours rather than normal terminally …

Survivin gene polymorphism association with papillary thyroid carcinoma

N Yazdani, FA Sayahpour, V Haghpanah… - … -Research and Practice, 2012 - Elsevier
Survivin expression is correlated with suppression of apoptosis in human solid tumors. A
polymorphism at position− 31 (G/C)(rs 9904341) has been associated with cancer risk in …

Survivin SNP-carcinogen Interactions in Oral Cancer

CJ Weng, YH Hsieh, MK Chen… - Journal of dental …, 2012 - journals.sagepub.com
In Taiwan, oral cancer is causally associated with environmental carcinogens. Survivin is an
anti-apoptotic protein and is generally considered a marker of malignancy. The current study …

Functional polymorphisms in promoter survivin gene and its association with susceptibility to bladder cancer in North Indian cohort

PK Jaiswal, A Goel, A Mandhani, RD Mittal - Molecular biology reports, 2012 - Springer
Survivin is a member of novel inhibitor of apoptosis protein family which expressed in
human cancers. The molecular detection of bladder cancer by targeting Survivin as a novel …