Endocrine-disrupting chemicals (EDCs) are substances generated by human industrial
activities that are detrimental to human health through their effects on the endocrine system …

Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …

Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio
rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for …

In 2016, the Frank R. Lautenberg Chemical Safety for the 21st Century Act became the first
US legislation to advance chemical safety evaluations by utilizing novel testing approaches …

The field of toxicology is on the cusp of a major transformation in how the safety and hazard
of chemicals are evaluated for potential effects on human health and the environment …

We previously integrated dosimetry and exposure with high-throughput screening (HTS) to
enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to …

Zebrafish (Danio rerio) is an emerging toxicity screening model for both human health and
ecology. As part of the Computational Toxicology Research Program of the US EPA, the …

The zebrafish embryo is a useful small model for investigating vertebrate development
because of its transparency, low cost, transgenic and morpholino capabilities, conservation …

Highlights•The Tox21 effort is to advance in vitro toxicological testing in the 21st
century.•Tox21 chemical library contains approximately 10,000 environmental chemicals.•A …

In recent times, machine learning has become increasingly prominent in predictive
toxicology as it has shifted from in vivo studies toward in silico studies. Currently, in vitro …