Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …

It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …

Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …

Myeloid derived suppressor cells (MDSCs) are bone marrow derived cells with
immunosuppressive properties. We have shown previously that MDSCs numbers are …

This mini-review focuses on leishmanicidal drugs that were sourced from small molecules
previously approved for other diseases. The mechanisms of action of these molecules are …

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune
dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine …

Tumor necrosis factor (TNF) is critical for controlling many intracellular infections, but can
also contribute to inflammation. It can promote the destruction of important cell populations …

Protozoa of the genus Leishmania cause a wide variety of pathologies ranging from self‐
healing skin lesions to visceral damage, depending on the parasite species. The outcome of …

The outcomes of Leishmania infection are determined by host immune and nutrition status,
parasite species, and co-infection with other pathogens. While subclinical infection and self …

Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …