The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can
recapitulate the in vivo architecture, functionality, and genetic signature of original tissues …

The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of
years, leading to the development of specialized mechanisms to actively limit the invasion of …

The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

CRISPR/Cas9 has become a powerful method for making changes to the genome of many
organisms. First discovered in bacteria as part of an adaptive immune system …

Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

Defining the complex role of the microbiome in colorectal cancer and the discovery of novel,
protumorigenic microbes are areas of active investigation. In the present study, culturing and …