Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …

Nitric oxide (NO) is an important signaling molecule in the human body, playing a crucial
role in cell and neuronal communication, regulation of blood pressure, and in immune …

Nitrogen-substituted cyclopropane compounds encompass a range of molecules with very
diverse chemical properties: aminocyclopropanes, N-cyclopropyl amides …

A new series of benzimidazole compounds including hydrazinecarbothioamide, 1, 2, 4-
triazole, 1, 3, 4-oxadiazole and imine function were synthesized starting from 5, 6-dichloro-2 …

The efficient synthesis of cyclopropyl boronic esters in library format using a diazomethane
flow reactor has been achieved. A pivotal component of the system is a fully automated tube …

Since high levels of nitric oxide (NO) are implicated in neurodegenerative disorders,
inhibition of the neuronal isoform of nitric oxide synthase (nNOS) and reduction of NO levels …

Introduction: Nitric oxide synthases (NOSs) are a family of enzymes that play an essential
role in synthesizing nitric oxide (NO) by oxidizing l-arginine. As previously reported, NO is a …

Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic
approach to target neurodegenerative disorders. However, the majority of the nNOS …

The 2-arylcyclopropylamine (ACPA) motif is often seen in biologically active compounds.
This review focuses on the synthesis of biologically active ACPAs and categorizes, by …

Positive allosteric modulators (PAMs) binding to the transmembrane (TM) domain of
metabotropic glutamate receptor 5 (mGluR5) are promising therapeutic agents for …