[HTML][HTML] SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside
SLC39A8 is an evolutionarily highly conserved gene that encodes the ZIP8 metal cation
transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent …
transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent …
[HTML][HTML] Genome-wide association studies of COVID-19: Connecting the dots
LC Ferreira, CEM Gomes, JF Rodrigues-Neto… - Infection, Genetics and …, 2022 - Elsevier
Genome-wide association studies (GWASs) are a research approach used to identify
genetic variants associated with common diseases, like COVID-19. The lead genetic …
genetic variants associated with common diseases, like COVID-19. The lead genetic …
[HTML][HTML] Associations between blood type and COVID-19 infection, intubation, and death
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …
testing resources, making the identification and prioritization of individuals most at-risk a …
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …
advance our understanding of the biology contributing to VTE, we conducted a genome …
[HTML][HTML] Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID‐19
A Rauch, J Labreuche, F Lassalle, J Goutay… - Journal of Thrombosis …, 2020 - Elsevier
Background Hypercoagulability seems to contribute to SARS‐CoV‐2 pneumonia
pathogenesis. However, age and metabolic syndrome are potential confounders when …
pathogenesis. However, age and metabolic syndrome are potential confounders when …
Cross-ancestry investigation of venous thromboembolism genomic predictors
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …
environmental and genetic determinants. Recent VTE genome-wide association studies …
[HTML][HTML] Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection,
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
[HTML][HTML] The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study
Y Li, H Liu, S Ye, B Zhang, X Li, J Yuan, Y Du, J Wang… - BMC medicine, 2023 - Springer
Background Endometriosis is recognized as a complex gynecological disorder that can
cause severe pain and infertility, affecting 6–10% of all reproductive-aged women …
cause severe pain and infertility, affecting 6–10% of all reproductive-aged women …
The genetics of portal hypertension: Recent developments and the road ahead
S Shalaby, L Ronzoni, V Hernandez‐Gea… - Liver …, 2023 - Wiley Online Library
Portal hypertension (PH), defined as a pathological increase in the portal vein pressure, has
different aetiologies and causes. Intrahepatic PH is mostly secondary to the presence of …
different aetiologies and causes. Intrahepatic PH is mostly secondary to the presence of …
[HTML][HTML] Clinical and genetic determinants of the fatty liver–coagulation balance interplay in individuals with metabolic dysfunction
Background & Aims The aim of this study was to examine the determinants of the interplay
between liver damage and the coagulation balance in individuals at risk of non-alcoholic …
between liver damage and the coagulation balance in individuals at risk of non-alcoholic …