The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2, 6 sialyltransferase 1), adds the
negatively charged sugar, sialic acid, to the terminal galactose of N-glycosylated proteins …

Sialic acid (SA), as the ultimate epitope of polysaccharides, can act as a cap at the end of
polysaccharide chains to prevent their overextension. Sialylation is the enzymatic process of …

Chemical biology has revealed the importance of sialic acids as a major signal in physiology
and disease. The terminal modification α-2, 6-sialic acid is controlled by the enzymes …

Background Ovarian cancer (OC) is the most fatal gynaecological malignancy and has a
poor prognosis. Glycosylation, the biosynthetic process that depends on specific …

A key to improving vaccine design and vaccination strategy is to understand the mechanism
behind the variation of vaccine response with host factors. Glycosylation, a critical modulator …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is
currently the third leading cause of cancer death. The aggressiveness of PDAC stems from …

Simple Summary Tumor cells accumulate sialylation in tissues via the coordination of
sialyltransferases and sialidases. Tumor sialylation can block receptor and ligand binding at …

Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …

Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the
development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells …

The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an
under-investigated area of research. In this study, we determined that ST6 β-galactoside α2 …