Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …

Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …

The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …

Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …

Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …

Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …

Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …

HIV-1 infection produces a long-lived reservoir of latently infected CD4+ T cells that
represents the major barrier to HIV-1 cure. The reservoir contains both intact and defective …