Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines

A Vander Straeten, M Sarmadi, JL Daristotle… - Nature …, 2024 - nature.com
Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP)
format could enhance vaccine access in low-resource communities by eliminating the need …

Opportunities and challenges in the delivery of mRNA-based vaccines

A Wadhwa, A Aljabbari, A Lokras, C Foged, A Thakur - Pharmaceutics, 2020 - mdpi.com
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …

Current trends in polymer microneedle for transdermal drug delivery

KAS Al-Japairai, S Mahmood, SH Almurisi… - International journal of …, 2020 - Elsevier
Transdermal drug delivery using microneedles is increasingly gaining interest due to the
issues associated with oral drug delivery routes. Gastrointestinal route exposes the drug to …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Strategies to reduce the risks of mRNA drug and vaccine toxicity

D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

[HTML][HTML] Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications

T Bauleth-Ramos, N El-Sayed, F Fontana, M Lobita… - Materials Today, 2023 - Elsevier
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the
transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical …

Chemical strategies to boost cancer vaccines

WH Li, YM Li - Chemical reviews, 2020 - ACS Publications
Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

From COVID-19 to cancer mRNA vaccines: moving from bench to clinic in the vaccine landscape

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Recently, mRNA vaccines have become a significant type of therapeutic and have created
new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation …