Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review

E Fudalej, M Justyniarska, K Kasarełło… - Ophthalmic …, 2021 - karger.com
Retinal ganglion cells (RGCs) play a crucial role in the visual pathway. As their axons form
the optic nerve, apoptosis of these cells causes neurodegenerative vision loss. RGC death …

Retinal glutamate neurotransmission: from physiology to pathophysiological mechanisms of retinal ganglion cell degeneration

I Boccuni, R Fairless - Life, 2022 - mdpi.com
Glutamate neurotransmission and metabolism are finely modulated by the retinal network,
where the efficient processing of visual information is shaped by the differential distribution …

Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

A Boccaccini, D Cavaterra, C Carnevale… - Molecular Aspects of …, 2023 - Elsevier
In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art

L Lambuk, MA Mohd Lazaldin, S Ahmad… - Frontiers in …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are neurons of the visual system that are responsible for
transmitting signals from the retina to the brain via the optic nerve. Glaucoma is an optic …

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and …

MM Zhu, JSM Lai, BNK Choy, JWH Shum… - Acta …, 2018 - Wiley Online Library
The benefits of physical exercise on health and well‐being have been studied in a wide
range of systemic and ocular diseases, including glaucoma, a progressive optic neuropathy …

Glaucoma pathogenesis and neurotrophins: focus on the molecular and genetic basis for therapeutic prospects

N Chitranshi, Y Dheer, M Abbasi, Y You… - Current …, 2018 - ingentaconnect.com
Background: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma
pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are …

[HTML][HTML] The association of physical activity with glaucoma and related traits in the UK Biobank

KM Madjedi, KV Stuart, SYL Chua, PY Ramulu… - Ophthalmology, 2023 - Elsevier
Purpose To examine the association of physical activity (PA) with glaucoma and related
traits, to assess whether genetic predisposition to glaucoma modified these associations …

[HTML][HTML] What is glaucoma?

D Križaj - Webvision: The Organization of the Retina and Visual …, 2019 - ncbi.nlm.nih.gov
Glaucoma, a leading cause of blindness in the world, can be challenging to diagnose
because symptoms often appear at late stage of the disease, and challenging to treat …

Three major causes of metabolic retinal degenerations and three ways to avoid them

A Kovács-Valasek, T Rák, E Pöstyéni, A Csutak… - International journal of …, 2023 - mdpi.com
An imbalance of homeostasis in the retina leads to neuron loss and this eventually results in
a deterioration of vision. If the stress threshold is exceeded, different protective/survival …

Role of BDNF/TrkB pathway in the visual system: therapeutic implications for glaucoma

BA Mysona, J Zhao, KE Bollinger - Expert review of ophthalmology, 2017 - Taylor & Francis
Introduction: Neuroprotective therapeutics are needed to treat glaucoma, an optic
neuropathy that results in death of retinal ganglion cells (RGCs). Areas covered: The …