Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer with poor
prognosis. Surgery, chemotherapy, and radiofrequency ablation are three conventional …

Pancreatic cancer is one of the solid tumors with the worst prognosis. Five-year survival rate
is less than 10%. Surgical resection is the only potentially curative treatment, but the tumor is …

The composition of the gut microbiome can control innate and adaptive immunity and has
emerged as a key regulator of tumor growth, especially in the context of immune checkpoint …

Immunotherapy, the most promising strategy of cancer treatment, has achieved promising
outcomes, but its clinical efficacy in pancreatic cancer is limited mainly due to the …

Background LncRNA-PACERR plays critical role in the polarization of tissue-associated
macrophages (TAMs). In this study, we found the function and molecular mechanism of …

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma
(PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune …

Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …

Pancreatic cancer is the deadliest disease, with a five-year overall survival rate of just 11%.
The pancreatic cancer patients diagnosed with early screening have a median overall …

Background AlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase
associated with the development, growth, and progression of multiple cancer types …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …