Epigenetic regulation of innate immune dynamics during inflammation
BA Caldwell, L Li - Journal of leukocyte biology, 2024 - academic.oup.com
Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …
inflammation by expressing a diverse array of cytokines and inflammatory mediators …
[HTML][HTML] Exploring the therapeutic potential of regulatory T cell in rheumatoid arthritis: Insights into subsets, markers, and signaling pathways
QY Su, HC Li, XJ Jiang, ZQ Jiang, Y Zhang… - Biomedicine & …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …
characterized by an imbalance between immunological reactivity and immune tolerance …
Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance
HE Amarasinghe, P Zhang, JP Whalley, A Allcock… - BMC genomics, 2023 - Springer
Background Monocytes are key mediators of innate immunity to infection, undergoing
profound and dynamic changes in epigenetic state and immune function which are broadly …
profound and dynamic changes in epigenetic state and immune function which are broadly …
[HTML][HTML] Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis
Monocytes can develop an exhausted memory state characterized by reduced
differentiation, pathogenic inflammation, and immune suppression that drives immune …
differentiation, pathogenic inflammation, and immune suppression that drives immune …
Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium
RB Ramos, N Martino, D Chuy, S Lu… - Journal of cell …, 2023 - journals.biologists.com
Endothelial dysfunction is a crucial factor in promoting organ failure during septic shock.
However, the underlying mechanisms are unknown. Here, we show that kidney injury after …
However, the underlying mechanisms are unknown. Here, we show that kidney injury after …
High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis
X Zhang, W Ji, X Deng, L Bo - Inflammopharmacology, 2024 - Springer
Sepsis is a complex, multifactorial syndrome characterized by a dysregulated host response
to infection, leading to severe organ dysfunction and high mortality rates among critically ill …
to infection, leading to severe organ dysfunction and high mortality rates among critically ill …
MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn
CY Lai, MC Hsieh, CM Yeh, PS Yang, JK Cheng… - …, 2022 - Elsevier
Originally characterized as an oncoprotein overexpressed in many forms of cancer that
participates in numerous cellular pathways, DEK has since been well described regarding …
participates in numerous cellular pathways, DEK has since been well described regarding …
Inhibition of miR‐146a Expression and Regulation of Endotoxin Tolerance by Rhesus Theta‐Defensin‐1
P Tongaonkar, KK Trinh, AJ Ouellette… - Mediators of …, 2023 - Wiley Online Library
Theta‐(θ-) defensins are pleiotropic host defense peptides with antimicrobial‐and immune‐
modulating activities. Immune stimulation of cells with lipopolysaccharide (LPS, endotoxin) …
modulating activities. Immune stimulation of cells with lipopolysaccharide (LPS, endotoxin) …
Succinate mediates inflammation-induced adrenocortical dysfunction
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation
leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex …
leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex …
Utilizing the codon adaptation index to evaluate the susceptibility to HIV-1 and SARS-CoV-2 related coronaviruses in possible target cells in humans
H Zhou, R Ren, SST Yau - Frontiers in cellular and infection …, 2023 - frontiersin.org
Comprehensive identification of possible target cells for viruses is crucial for understanding
the pathological mechanism of virosis. The susceptibility of cells to viruses depends on …
the pathological mechanism of virosis. The susceptibility of cells to viruses depends on …