Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …

Background Monocytes are key mediators of innate immunity to infection, undergoing
profound and dynamic changes in epigenetic state and immune function which are broadly …

Monocytes can develop an exhausted memory state characterized by reduced
differentiation, pathogenic inflammation, and immune suppression that drives immune …

Endothelial dysfunction is a crucial factor in promoting organ failure during septic shock.
However, the underlying mechanisms are unknown. Here, we show that kidney injury after …

Sepsis is a complex, multifactorial syndrome characterized by a dysregulated host response
to infection, leading to severe organ dysfunction and high mortality rates among critically ill …

Originally characterized as an oncoprotein overexpressed in many forms of cancer that
participates in numerous cellular pathways, DEK has since been well described regarding …

Theta‐(θ-) defensins are pleiotropic host defense peptides with antimicrobial‐and immune‐
modulating activities. Immune stimulation of cells with lipopolysaccharide (LPS, endotoxin) …

The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation
leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex …

Comprehensive identification of possible target cells for viruses is crucial for understanding
the pathological mechanism of virosis. The susceptibility of cells to viruses depends on …