Formation and integration of new neurons in the adult hippocampus
A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Of men and mice: modeling the fragile X syndrome
R Dahlhaus - Frontiers in molecular neuroscience, 2018 - frontiersin.org
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
Local translation in perisynaptic astrocytic processes is specific and changes after fear conditioning
Local translation is a conserved mechanism conferring cells the ability to quickly respond to
local stimuli. In the brain, it has been recently reported in astrocytes, whose fine processes …
local stimuli. In the brain, it has been recently reported in astrocytes, whose fine processes …
Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA binding protein whose deficiency impacts many brain functions, including …
(FMRP), an RNA binding protein whose deficiency impacts many brain functions, including …
Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
H Li, L Xu, W Jiang, X Qiu, H Xu, F Zhu, Y Hu, S Liang… - Cell Reports, 2023 - cell.com
Cognitive impairment has been associated with an age-related decline in adult hippocampal
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …
Targeting MDM2 for novel molecular therapy: Beyond oncology
The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human
cancers; it is not only the best‐documented negative regulator of the p53 tumor suppressor …
cancers; it is not only the best‐documented negative regulator of the p53 tumor suppressor …
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice
Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental
retardation protein (FMRP). How FMRP regulates neuronal development and function …
retardation protein (FMRP). How FMRP regulates neuronal development and function …
FMRP modulates the Wnt signalling pathway in glioblastoma
Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP),
which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers …
which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers …
BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids
C He, NC Kalafut, SO Sandoval, R Risgaard… - Cell Reports …, 2023 - cell.com
Our machine-learning framework, brain and organoid manifold alignment (BOMA), first
performs a global alignment of developmental gene expression data between brains and …
performs a global alignment of developmental gene expression data between brains and …