Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …

Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Osteosarcoma, a bone cancer usually seen in children and young adults, is generally a high-
grade malignancy presented by extreme metastases to the lungs. Osteosarcoma has a …

Recent clinical trials using immunotherapy have demonstrated its potential to control cancer
by disinhibiting the immune system. Immune checkpoint blocking (ICB) antibodies against …

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

Recent advances in the understating of tumor immunology suggest that cancer
immunotherapy is an effective treatment against various types of cancer. In particular, the …

Due to imbalances between vascularity and cellular growth patterns, the tumour
microenvironment harbours multiple metabolic stressors including hypoxia and acidosis …

Radiofrequency ablation (RFA) promotes tumor antigen-specific T cell responses and
enhances the effect of immunotherapy in preclinical settings. Here we report that the …

Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population
of the immune system. They play a pivotal role in the establishment of the tumor …