The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Drug delivery with carbon-based nanomaterials as versatile nanocarriers: progress and prospects

SK Debnath, R Srivastava - Frontiers in Nanotechnology, 2021 - frontiersin.org
With growing interest, a large number of researches have been conducted on carbon-based
nanomaterials (CBNs). However, their uses are limited due to comprehensive potential …

Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats

R Pahuja, K Seth, A Shukla, RK Shukla, P Bhatnagar… - ACS …, 2015 - ACS Publications
Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major
hurdle for successful therapy in Parkinson's disease (PD), a neurodegenerative disorder …

Carbon nanotubes: Current perspectives on diverse applications in targeted drug delivery and therapies

M Rahamathulla, RR Bhosale, RAM Osmani… - Materials, 2021 - mdpi.com
Current discoveries as well as research findings on various types of carbon nanostructures
have inspired research into their utilization in a number of fields. These carbon …

Carbon nanostructures: The drug and the delivery system for brain disorders

TK Henna, VR Raphey, R Sankar, VKA Shirin… - International Journal of …, 2020 - Elsevier
Neurodegenerative disorders and brain tumors are major pathological conditions affecting
the brain. The delivery of therapeutic agents into the brain is not as easy as to other organs …

Theranostic applications of multifunctional carbon nanomaterials

S Masoudi Asil, ED Guerrero, G Bugarini, J Cayme… - View, 2023 - Wiley Online Library
Nanobiotechnology is one of the leading research areas in biomedical science, developing
rapidly worldwide. Among various types of nanoparticles, carbon nanomaterials (CNMs) …

Carbon nanotubes-based drug delivery to cancer and brain

Q Guo, X Shen, Y Li, S Xu - Current Medical Science, 2017 - Springer
Current treatments for cancer and the central nervous system diseases are limited, partly
due to the difficulties posed by the insolubility, poor distribution of drugs among cells and …

Nanotube breakthroughs: unveiling the potential of carbon nanotubes as a dual therapeutic arsenal for Alzheimer's disease and brain tumors

D Elsori, G Rashid, NA Khan, P Sachdeva… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) and brain tumors are debilitating neurological conditions that pose
significant challenges in current medical practices. Existing treatment options for AD …

Strategies for enhancing the permeation of CNS-active drugs through the blood-brain barrier: a review

I Zeiadeh, A Najjar, R Karaman - Molecules, 2018 - mdpi.com
Background: The blood brain barrier (BBB) is a dynamic and functional structure which
poses a vast challenge in the development of drugs acting on the central nervous system …

Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial …

AAH Abdellatif, HA Mohammed, RA Khan… - Nanotechnology …, 2021 - degruyter.com
This review focuses on nano-structured delivery devices prepared from biodegradable and
biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides …