Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Packaging the long and fragile genomes of eukaryotic species into nucleosomes is all well
and good, but how do cells gain access to the DNA again after it has been bundled away …

Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …

Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Nucleosomes wrap DNA and impede access for the machinery of transcription. The core
histones that constitute nucleosomes are subject to a diversity of posttranslational …

Differentiated somatic cells can be reprogrammed to totipotent embryos through somatic cell
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …

Regulation of transcription is a tightly choreographed process. The establishment of RNA
polymerase II promoter proximal pausing soon after transcription initiation and the release of …

Background The human endometrium is a highly dynamic tissue whose function is mainly
regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of …

Embryonic stem cells (ESCs) have transcriptionally permissive chromatin enriched for gene
activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 …